The Scientific Committee on Consumer Safety (SCCS) of the EU has issued a risk assessment that finds the use of the nanoform of piperazine derivative HAA299 to be safe in skin cosmetics, as long as the concentration does not exceed 10%. Nevertheless, use as inhalants are to be avoided because of indications of lung inflammations.
As the basis for their harmlessness statement, the authors cite previously available studies showing that nano HAA299 does not penetrate the skin or does so only in very small quantities.
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