▪︎ CLP, SDS
Resorcinol: France’s Draft Proposal for Classification as an Endocrine Disruptor Could Be a Model
France has submitted a harmonized classification and labeling dossier (CLH dossier) for resorcinol to the ECHA. In it, the French authority proposes classification of the substance as an endocrine disruptor of category 1 for humans (ED HH). Since the proposal is the first of its kind, it could serve as a model for further classifications.
Resorcinol as a precedent
Commission Delegated Regulation (EU) 2023/707 amended the CLP Regulation to include new hazard classes, including endocrine disruptors (ED HH and ED ENV). The chemical compliance world therefore eagerly awaits the first classification proposals and how regulatory authorities will apply the classification criteria. Resorcinol leads the way.
Studies confirm ED effect
For years, the substance has been suspected disrupting the function of the thyroid gland. However, classification as an endocrine disruptor has so far failed due to disagreements among experts. Meanwhile, however, it is considered proven that resorcinol can penetrate the skin and inhibit the effect of the key enzyme thyroid peroxidase (TPO).
Substance with a wide range of uses
Resorcinol is a widely used basic substance. It is used to manufacture tires, rubber products, adhesives and industrial resins, cosmetics, personal care products, and many others. In March 2021, the EU Commission’s Scientific Committee on Consumer Safety (SCCS) deemed resorcinol safe – provided its concentration in oxidative hair dyes, hair lotions and shampoos does not exceed 1.25 percent.
Next steps
The consultation on the CLH report ends on March 21. After that, ECHA's Committee for Risk Assessment (RAC) will discuss the classification proposal and prepare an opinion.
Further classification proposals in the pipeline
Belgium and Austria have also submitted CLH dossiers for potential endocrine disruptors. Belgium has proposed classifying the substance propyl 4-hydroxybenzoate (propyl paraben) as an endocrine disruptor of category 1 in the environment (ED ENV 1). Austria is taking a similar approach with the substances 3-aminopropyldiethylamine (DEAPA) and 3-aminopropyldimethylamine.
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